The popular ingredients for longevity supplement of 2023.
In the face of increasing global population aging, longevity is the eternal pursuit of all kinds of nations of people. Industry experts describe the growing emphasis on longevity as more of an evolution than a revolution.
“How to stay young without surgery?Supplements of Longevity and anti-aging are always popular on the supplement market, what are the most popular ingredients in Longevity supplements in 2023?”
1. NMN
NMN(Nicotinamide mononucleotide),the star of all kinds of anti aging supplement, NMN-containing healthcare products and cosmetics are becoming increasingly popular in North America, Europe and China. The global NMN market was valued at US$253 million in 2020 and is projected to reach US$386 million by the end of 2027.Atually what matters most is NAD+ which is an essential molecule that is involved in myriad critical cell functions.Functions of NAD+:
-Cell growth and repair, metabolism
-DNA repair and survival
-Cellular respiration, which is the biological process by which our cells take glucose and oxygen, and convert them into energy
-Regulation of gene expression, the process by which our genetic information is used to make amino acids and proteins – the very building blocks of life.
Increasing NAD+ levels translate to improved metabolism and cellular activities which can manifest in a variety of health benefits. However, NAD+ can not be taken directly because NAD+ is not absorbed well by the digestive system, nor is it directly taken up by cells. The upshot of this means that NAD+ alone does not make for a particularly good supplement. It is far better to take an NAD+ precursor – one of the key building blocks – so that your body is able to make vital NAD+ and top up those declining levels.
The precursor NMN is an excellent starting point for the vital molecule that facilitates thousands of reactions for cell energy, DNA repair, and stress reduction.
Although NMN is quite hot on the market,you still can not ignore FDA’s restrictions on NMN, NMN may not be sold as a supplement according to the FDA,you may not likely to search out NMN products on amazon,but can be find in some company’s websites as a research supplement use.
So, while we’ll be continuing to keep an eye on future FDA decisions, for the moment, we are still confident that NMN is a supplement that can make a real difference to your NAD+ levels, boosting the amount of the important antiaging molecule and promoting healthspan and healthy aging.
2. Spermidine
Spermidine is quickly becoming a big name on the supplement scene. If taken regularly, the supplement can significantly impact health and lifespan.How does it work?
Study show that spermidine induces autophagy, the process of cellular rejuvenation, through the TOR kinase pathway. Autophagy occurs naturally in cells as it regulates cellular metabolism. Autophagy also balances nutrients during cell stress so can be can be accelerated by fasting or by caloric restriction mimetics (CRMs) like spermidine that mimic fasting’s effects on the body.
During autophagy, cells reuse their old or damaged organelles to achieve cellular renewal and its antiaging benefits. Indeed, autophagy is thought to limit inflammation and oxidative stress, the main culprits involved in aging and related diseases.
our natural spermidine levels gradually decline with age,although we can get from natural food as vegetables,soybean products,cereals,a variety of cheese, the most effective way to attenuate declining spermidine levels is by taking longevity supplements.
3. Urolithin A
Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria. It belongs to the class of organic compounds known as benzo-coumarins or dibenzo-α-pyrones.
One the key benefits of urolithin A is boosted cellular energy in the mitochondria.What’s the meaning of this? Mitochondrial function declines with age, impairing the mitochondria’s ability to produce enough energy. Mitochondrial dysfunction is one of the nine ‘hallmarks of aging’ that cause cellular and molecular damage to the body that can lead to age-related illness. Known as an antagonistic hallmark, mitochondrial dysfunction can cause loss of muscle strength, which many people experience from their 40s onwards.
Therefore, urolithin A supplements could be an effective and accessible tool to improve health and longevity in older people. Considering that the aging population is growing exponentially, with projected figures predicting that there will be 1 billion people aged over 65 by 2030, longevity supplements like urolithin A are worth taking seriously.
4. PQQ
PQQ supplements are claimed to increase energy levels, mental focus, and longevity, it is also called methoxatin, is a vitamin-like compound that exists naturally in soil and a variety of foods, including spinach, kiwi, soybeans, and human breastmilk.
PQQ’s exact function in humans remains somewhat undetermined, but it’s renowned for its potent antioxidant effects. It’s also thought to be involved in a variety of cellular processes, including protecting nerve cells against damage. What’s more, PQQ supports proper mitochondrial function and the cellular development of new mitochondria, though its exact mechanisms are still unclear,this part if quite similar to urolithin A.
Of course,apart from this new innovative longevity supplement,we should never forget about the basic ones as CoQ10, Resveratrol, Broccoli extract,etc.